AI for time-resolved imaging: from fluorescence lifetime to single-pixel time of flight

Time-resolved imaging is a field of optics which measures the arrival time of light on the camera. This thesis looks at two time-resolved imaging modalities: fluorescence lifetime imaging and time-of-flight measurement for depth imaging and ranging. Both of these applications require temporal accuracy on the order of pico- or nanosecond (10−12 − 10−9s) scales. This demands special camera technology and optics that can sample light-intensity extremely quickly, much faster than an ordinary video camera. However, such detectors can be very expensive compared to regular cameras while offering lower image quality. Further, information of interest is often hidden (encoded) in the raw temporal data. Therefore, computational imaging algorithms are used to enhance, analyse and extract information from time-resolved images. "A picture is worth a thousand words". This describes a fundamental blessing and curse of image analysis: images contain extreme amounts of data. Consequently, it is very difficult to design algorithms that encompass all the possible pixel permutations and combinations that can encode this information. Fortunately, the rise of AI and machine learning (ML) allow us to instead create algorithms in a data-driven way. This thesis demonstrates the application of ML to time-resolved imaging tasks, ranging from parameter estimation in noisy data and decoding of overlapping information, through super-resolution, to inferring 3D information from 1D (temporal) data